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KMID : 1225720140060050463
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Allergy, Asthma & Immunology Research : AAIR
2014 Volume.6 No. 5 p.463 ~ p.466
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The Impact of Asthma Control on Salivary Cortisol Level in Adult Asthmatics
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Shin Yoo-Seob
Liu Jing Nan
Kim Joo-Hee
Nam Young-Hee
Choi Gil-Soon
Park Hae-Sim
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Abstract
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The Impact of Asthma Control on Salivary Cortisol Level in Adult Asthmatics
Yoo Seob Shin,1 Jing Nan Liu,1 Joo-Hee Kim,2 Young-Hee Nam,3 Gil Soon Choi,4 Hae-Sim Park,1 and Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group
1Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
2Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
3Department of Internal Medicine, Dong-A University School of Medicine, Busan, Korea.
4Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Correspondence to: Hae-Sim Park, PhD, Department of Allergy and Clinical Immunology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea. Tel: +82-31-219-5196; Fax: +82-31-219-5154; Email: hspark@ajou.ac.kr
Received September 26, 2013; Revised November 08, 2013; Accepted November 29, 2013.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Go to:AbstractINTRODUCTIONMATERIALS AND METHODSRESULTSDISCUSSIONNotesACKNOWLEDGMENTSReferencesAbstract
Asthma is a chronic disease causing psychological stress which leads to the activation of hypothalamus-pituitary-adrenal axis. The purpose of this study is to compare morning salivary cortisol levels in persistent asthma patients according to their disease severities and control status. Total 206 adult asthma patients were recruited from four university hospitals. Spirometry, questionnaire of Asthma Quality of Life (AQOL) and Asthma Control Test (ACT) were completed, and saliva samples were collected prospectively to measure morning cortisol level. The mean patient age was 56.5±15.3 years with mean asthma duration of 9.1±11.1 years. Sixty five patents (31.6%) were classified as mild persistent asthma, and 141 patients (68.4%) were classified as moderate persistent asthma according to the Expert Panel Report 3. The mean predicted FEV1 was 88.8%±18.4%, and the methacholine PC20 was 9.6±8.5 mg/mL in all study population. The mean ACT score for all patients was 19.9±3.6, and there were 71 (34.5%) patients in poorly controlled and 135 (65.5%) in well controlled asthma. The poorly controlled asthma patients were characterized by significantly lower FEV1 (84.6%±17.6% vs 91.1%±18.5%, P=0.018), lower AQOL scores (46.0±13.9 vs 73.8±26.3, P<0.001), and lower salivary cortisol levels (0.14±0.08 vs 0.18±0.11 μg/dL, P=0.04) compared to well controlled asthma. The ACT score was significantly related to salivary cortisol levels (P=0.034) after adjusting for age. There was no significant difference in salivary cortisol levels (0.17±0.12 vs 0.16±0.08, P=0.725) when analyzed according to the dose of used corticosteroid and lung function. Asthma control status affects morning salivary cortisol level. Measuring the morning salivary cortisol level might be a simple and new way to assess asthma control status.
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KEYWORD
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Asthma, asthma control test, salivary cortisol, stress
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